Piling Gold in the Prostate

Maximal Data Piling in Discrimination

In a binary discrimination problem, a linear classifier finds a linear hyperplane that separates two classes by partitioning the data space. Especially in a High Dimension Low Sample Size (HDLSS) setting, there are linear separating hyperplanes such that the projections of the training data points onto their normal direction vectors are identically zero, or some non-zero constant. Of interest i...

Piling of multiscale random models

This paper considers random balls in a D-dimensional Euclidean space whose centers are prescribed by a homogeneous Poisson point process and whose radii are forced to be in a finite interval with a power-law distribution. Random fields are constructed by counting the number of covering balls at each point. We are mainly interested in the simulation of these fields and in the empirical estimatio...

insertion of intraprostate gold fiducial markers in prostate cancer treatment

Piling Up, or Floating Away

Prostate MRS in the presence of gold seed fiducial markers

MR Spectroscopy (MRS) has great potential for guiding radiotherapy of prostate cancer by identifying bulky and/or high grade tumors suitable for dose escalation (1,2). However, image guided therapy typically employs permanently implanted gold seed fiducial markers (GSFM), which aid in daily prostate localization prior to treatment. The impact of these gold seed markers on the quality of MRS is ...